Hopefully this will work out and spare me the ordeal of last time. The dosage and schedule are determined by the person's size and type of cancer. These symptoms can last for several months or longer after treatment ends. You don't sound negative, you just sound disheartened that after following all advice you are still suffering and also that you are finding treatment difficult. I know what to expect now and feel better prepared for chemo cycle 5, 2nd of Docetaxel . Not able to advise, but sending loads of hugs to get you through this traumatic part of your journey xxxxxxxx, You haven't gone wrong Dolbycat, as you said it effects everyone differently. As the saying goes, "Hindsight is 20/20 . Epiphora One of the most major Taxotere side effects is epiphora or, in simple terms, watery eyes. The 3rd week I just start to feel normal.and then whoops, time for another infusion to start the cycle. The mouth issues I suffered with all the way through chemo (didn't have thrush) but would say the mouth part was my worst SE. Humor can also lessen anxiety and discomfort, allowing cancer patients to talk more openly about their concerns and fears. Furthermore, the overall response rate for docetaxel in the intent-to-treat population (42.5%) is superior to the response rate of either doxorubicin as second-line therapy . I've had all three FEC sessions and coped really well and was positive and active. Can eat, not been sick, not taken antisickness meds, but nausia with ukky taste but poor sleep got worse. Common reported side effects of Taxotere (docetaxel) include: Injection site pain or swelling Temporary hair loss Nausea Vomiting Diarrhea Constipation Loss of appetite Fingernail or toenail changes Does anyone have any suggestions of anything that can help me .. X, Reading all the comments, many of us have been through the mill with this 4th treatment. I am sorry to read that the chemo is hitting you so hard.If there is a magic answer i never found it but the things that were usefull to me were -dont eat befor chemo and walk afterwards.If you can get your body going-even if it is to the end of the road and back and you feel like **** I found it seemed to get your system going at least a bit. I was informed that I would need a mastectomy as to the way the tumour is growing in the breast. All the very best for the next treatment, I will think about you when I have mine next Friday. Carry on being her strength and pass on my love to her xx. With Taxotere, I have had bad stomach aches, back aches, extremely low energy, trouble tasting food, and minimized appetite. Even my vision has been effected. These are some of the most common or important side effects: Allergic reactions are possible with this medication. Docetaxel is its generic name, and it belongs to the taxane class of drugs. Please consult your healthcare provider with any questions or concerns you may have regarding your condition. It helps with pain so uncomfortable in spasms but endurable if I dont climb too many stairs with lead legs, It may have helped the mouth too, the stronger dose did make me reach for the bonjella where moments before was ok. 10 days of horrible tastes and softer foods has been hard. Your doctor may prescribe medication to take before your treatment to help decrease the risk of edema. I shall follow your journey with hope and healing. Xx, Hi Berylynn, thank you for the support, we are certainly in this together for you are experiencing some of the same issues as me with this dreadful new chemo. Docetaxel also was found to be highly effective in patients with a poor prognosis, having metastases in three or more organs (53%), and/or visceral sites of disease (47%). I'm on my 6th Dox this week, (last one) and I mentioned to my oncologist on 3rd dose that i was awake ALL night on the steroids - I had been prescribed 8mg Dexamethasone twice daily starting day before and finishing on day after Dox. Please. I have the district nurse for the 5 injections following chemo and also the Picc line flushes as not left the house since last chemo, not had the energy. Taxotere is part of a family of drugs known as taxanes that work by preventing cell growth. Sorry to be such a negative misery , I am usually upbeat and positive but wanted to ask if these cycles compound with the side effects as I am not sure I could cope with another 2 cycles. Shari S. (Breast Cancer, Invasive Ductal Carcinoma (IDC),Triple Positive, Stage 4). Sorry to hear your wife suffered as she did. She is on this dose denseShe is on this dose dense regiment; every two weeks; 4 rounds of AC followed by 4 rounds of Taxol (and I think it's five day after Nuelasta shots). I'm fortunate in that my husband is self employed. While we were driving home - it's a nice, sunny, fairly warm day - Moopy observed that getting out was a reminder of what our life will be like again. Your Wife is unique! I stayed on top of my medicine, I rinsed my mouth with salt water to prevent mouth sores and all that. Scared to the point of not being able to sleep properly. Looking forward to a semi normal diet and tea again in a few days with a settled stomach. diarrhea. I want to speak with the Oncologist about the strength of Docetxel used it it seems very high at 200mg. Paracetamol Ibuprofen/codiene didn't work. Fatigue. Your oncology care team can recommend medications to relieve diarrhea. The drug can cause tear duct closures which can cause permanent tearing. My last infusion was in December. You could talk to your doctor about your concerns and see if they can give you a lower dose if necessary?They also have pills for most things-I was told that they could probably help with everything but the tiredness. If you feel unwell or have any of these signs, tell them straight away. My GP has just upped the antibacterial and anti fungal meds to double strength to hopefully help clear the thrush. This is known as a cycle. It was tough going, but I got there. You should preferably avoid the regular consumption of grapefruits and grapefruit juice while taking DOCEtaxel. I am definitely not one of those people who gain weight due to chemo. I have been given so many tablets with this cycle which need to be taken with food but find eating almost impossible due to chemo mouth explosion of thrush despite being on medication. TC. Docetaxel. If you notice any changes in how you feel during the infusion, let your nurse know immediately. I never threw up really, but I had underlying nausea all the time. As grumpy has already said there are many pills/potions they can introduce to help combat side effects - my hubby still has to take medicine to combat bowel problems due to the coctail of painkillers he is now on. Perseverance!! The end is now in sight and just keep thinking what a good job the chemo is doing getting rid of this nasty disease. Then I will start on radiotherapy. Docetaxel belongs to the group of medicines called antineoplastics (cancer medicines). One of the most major Taxotere side effects is epiphora or, in simple terms, watery eyes. (I too read somewhere that grapefruit can make the side-effects of the drug worse). I don't know about AC, but when I was on TC, I was told that it's not cumulative, so I would not be feeling worse as chemo progressed.Good luck to Donna, I hope she gets the rest she needs. You will have got through it now though? My poor hubby had to give them me.but they hurt and make me have achy legs.plus with the chemo sleepless nights. worst: [adverb] to the extreme degree of badness or inferiority. Good luck with your next cycle and hopefully you too will benefit from the treatment. xx, My consultant reduced my injection strength so I had to endure 10 injections as prescribed. Receive the latest resources and updates in your inbox. Each mL contains 40 mg docetaxel (anhydrous) and 1040 mg polysorbate 80. Premedication is required with Docetaxel. Of course, we each respond as individuals. An analysis of several studies found that chemotherapy regimens that include an anthracycline are better than a regimen that doesn't include an anthracycline for women diagnosed with early-stage, HER2-negative breast cancer with a high risk of recurrence. I had no sleepless issues on A/C but on Taxol I did - first meds given me by my Chemo Dr did not help only gave horrible nightmares (which I don't normally have) but my PA switched me to the lowest does of another med and it worked great.It's great to ask for input of experiences BUT There are NONE of us who can tell you what your wife will experience - we are EACH so unique in how our bodies handle the onslaught of the battle - we can tell our stories but we cannot tell you that what happened to/with us will happen for your wife.Susan, I too had AC followed byI too had AC followed by taxol. Weekly taxol : which days will be worst. TAXOTERE is sterile, non-pyrogenic, and is available in single-dose vials containing 20 mg (0.5 mL) or 80 mg (2 mL) docetaxel (anhydrous). This medication contains alcohol and may cause intoxication. Still on the journey. Please consult with your healthcare team regarding the use of these agents and all over the counter medications/supplements while on therapy. Fatigue is very common as a side effect. Hi, I have a good support system at home who do just about everything as I have been bed or sofa bound for the last 10 days with just small walks around the house to keep the circulation going. You are not alone in this. I am hopeful that the next two cycles will be less of a shock to the system. Found the freeze gell hit the joint areas better and gave relief. So my advice is dont be scared to ring the chemo hotline, they know what to advise and whether or not you should go in.. Even if your menstrual cycle stops or you believe you are not producing sperm, you could still be fertile and conceive. I will watch out for you and we can support each other. I end up with wet pillows at nightnever had that with Tamaxifen or in 50s. (2013) demonstrated that nano-formulation improved plasma PK and tumor delivery of Doc compared to the unprocessed Doc. My tumour is responding well as confirmed by a recent MRI between cycle 3 and 4 so I need to continue to hopefully get through these last two cycles. This typically begins two to three weeks after treatment starts. Keep reading to learn more about what to expect on your worst days on Taxotere. The only really bad side effect I had was the fatigue. DelveInsight has compiled the symposium's major highlights so that one does not miss out on these expansions . I have previously been prescribed mouth wash, gel and drops to no avail this time round. Platelets help your blood clot, so when the count is low you are at a higher risk of bleeding. I expected it to be tough but it has nearly broken me. . 2.6 Premedication Regimen. She is also tired of taking pills. But it was worth it when looking at the larger picture. For prostate cancer, chemo drugs are typically used one at a time. Will try the mouthwash as that is also a problem, I have a drink and seconds later my mouth is so dry again! Avoid raw fruits, vegetables, whole grain bread, cereals, and seeds. Researchers spent YEARS finding chemotherapy compounds that could attack prostate cancer cells. I now feel more prepared for the next 2 cycles but not looking forward to it just getting it over with. For cycle 2 I used a great mouthwash - Difflam and have had no sore mouth problems since. I also drank an ensure every day the week of chemothat does give you a boost. The month of October 2008 was one of the worst in New York Stock Exchange history, with three of the top 10 largest single-day drops ever recorded during the month. My doctors have been very good and have assured me that they caught it early. Thank you for the support, hope you are doing well. I turned 52 just a few days after that first Taxotere Chemo treatment. I was initially told to have the chemo in the hope they could conserve the breast! It's now a week since my 1st cycle of Docetaxel following 3 cycles of FEC, it has been a dreadful week where the treatment has thrown back every side effect possible. Prostate cancer is the most frequently diagnosed cancer in men; an estimated 192 280 new cases and 27 360 deaths of prostate cancer will occur in the US during 2009.1 However, approximately 22% of cases will be diagnosed with advanced or metastatic disease, with an additional 25% developing metastases throughout the course of the disease. I know that treats are not offically a cure but i try and put nice things in the bad days so not everything is about cancer . Really sorry to read that you having such a s---- time with your current chemo treatment. I took nausea tabs even when I wasn't nausaus, but it made little difference. 10 year old is self sufficient. Copyright 2000-2022 Cancer Survivors Network. worst daysfor me it was the week after the infusion..I just fall apart.tired, ache, intestinal issuesetc. The only things I could taste were sweets. Everything tasted like cardboard, which sucked because I love to eat. So into hospital she went each time. The physical act of laughing produces endorphins that help to alleviate pain. Men who are treated with this medication should use effective birth control during and for 4 months after the last dose. I ended up in hospital 4 days after treatment.. You may also experience difficulty breathing, joint stiffness, pain, and even behavioral changes. It is a horrid drug and going through the side effects of chemo is just unbearable at times (for me and some others unfortunately!). Some of the chemo drugs used to treat prostate cancer include: Docetaxel (Taxotere) Cabazitaxel (Jevtana) Mitoxantrone (Novantrone) Estramustine (Emcyt) In most cases, the first chemo drug given is docetaxel, combined with the steroid drug prednisone. I haven't had much information about that yet. Xx, Thanks Berylynn. Hi, not sure if my experiences will help you. No cancer cells were found, and she was deemed "no evidence of disease". It won't be long until you to are in a position to help others with your experiences of the journey we all find ourselves on. After starting docetaxel, many men experience the improvements in disease-related symptoms, including pain, fatigue and loss of energy. Docetaxel works by disrupting the microtubular network in cells, which is essential for cell division and other normal cellular functions. I was given Co-Codomol 500mg at the hospital when my temperature spiked. Progression-free survival was 2-3 months for both groups. Then starting in June 2014, I had 15 doses of Radiotherapy. Week Two was always the rebuild. The prospect of 12 weekly taxol is a bit daunting. Make sure that those around you understand that while the pain peaks, you need absolute rest. Nutrition is an important part of your care. White blood cells (WBC) are important for fighting infection. May your good health continue. They can help you decide what will work best for you. I have had problems with temperaturechilly and drafts set off cough and shivering, warm and cosy sweating. It happens most often in the legs and feet, but it isnt unusual to see swelling in the hands, arms, and abdomen. That finished months ago, but she's still whacked by the docetaxel on and off. Had tummy issues mostly diarrhoea but managed to get a good stopper tablet. Add extra flavor to meat or fish by marinating it in sweet juices, sweet and sour sauce, or dressings. fatigue. And pineapple sounds a good idea too! You may wear nail polish, but not fake nails. So going through the rest of the horror. While on cancer treatment, and for a period after, you may need to adjust your schedule to manage fatigue. My experience was that how I felt after my following treatments was similar to my reaction after the first treatment. Do not cut cuticles or ingrown nails. I had my 2nd cycle of Docetaxel yesterday. Stick with it. Differences in clearance for the two PRINT particles suggest that shape plays a role in reducing clearance by the MPS and enhancing tumor delivery. It was just the drugs working their way through my system. What Are Some Reasons To Buy A Home In Fireside At Desert Ridge? Painkillers, she had all the same things as you. If the area of injection becomes red, swollen, or painful at any time during or after the injection, notify your care team immediately. Brady appears to be expanding his brand rapidly in 2023. White endeared himself to Jets fans over the last two years with his inspiring play as Zach Wilson's backup. Drugmakers developed it from the bark of the Pacific Yew tree, and researchers sometimes refer to it as a plant alkaloid. Notify your oncology care team if your mouth, tongue, inside of your cheek or throat becomes white, ulcerated, or painful. Hi, I had my 1st infusion of Taxotere on Monday. Do not floss or use toothpicks and use a soft-bristle toothbrush to brush your teeth. Pineapple is good for helping the nasty taste and I know someone who sucked frozen pineapple cubes and this helped her a lot. The infusion will be slowed or stopped if this occurs. TAXOTERE (docetaxel) injection, for intravenous use . Worst days when i was on 3chemo meds, taxotere, carbon, and Herceptin, were 3-5 days after. At that time, TAXOTERE was typically used for advanced prostate cancer, after all other treatments had failed. 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